The absolute best way to get around is by using an aircraft charter.
One of the key advantages of having an air charter is that you set your arrival and departure time. If you need a shipment to be there for 2:00pm it is arranged that the plane arrives at 2:00pm. The cargo does not have to land at 10:00am and wait around for a couple of hours since the next flight is not until 4:00pm. This is one of the key strengths of using a private aircraft charter, it allows maximizing time efficiency.
There is a myth that flying on an air charter is very expensive. That is not true when you look at the numbers. A mid size plane can be chartered for around $5,000/hr. In 4-5 hours you can get freight from most any major city to another within North America. The time advantage as already discussed makes the value of flying this way even better.
You may be wondering why some larger companies don’t just buy their own planes instead of using charters. Using an aircraft charter regularly is likely much cheaper than owning your own aircraft. This is true even for larger corporations. There is extensive maintenance required on the plane. It also takes specialized mechanics to keep the plane flying. Having them available when you need them through a reliable air charter broker can give you the best of both worlds. It has the planes well maintained and available and keeping your costs down.